Efficacy Testing (cellular and animal)<

• Microbiology
  in vitro studies     Download PDF

  - MIC determination (NCCLS standard procedures and ATCC reference strain)

  • Bacterial panels include Gram-positive, Gram-negative, and anaerobes.
  • Fungal panels include yeast, and filamentous fungi

  - Cross-resistance studies using panels of strains expressing most known drug resistance mechanisms e.g. efflux, ßlactamase production, etc.
  - De novo resistance development studies
  - Kill-time studies
  - Post-antimicrobial effect (PAE) studies
  - Effect of body milieus on activity
  - Determination of activity on recently collected clinical isolates using over a 4000 bacterial and fungal clinical isolate collection
  - High-throughput screening of activity using the Beckman2000 automated workstation
  - Drug-drug interaction studies
  
  




• Microbiology
  in vivo Efficacy studies (1 compound per week)     Download PDF
  

  - Thigh Infection (S. aureus)
  - Systemic acute S. aureus infection model
  - Systemic acute E. coli infection (IP/IV) model
  - Lung S. pneumoniae infection model
  - Systemic acute C. albicans infection model
  - Lung A. fumigatus infection model (Immuncompromized)
  - Systemic A. fumigatus infection model
  - Systemic C. glabrata infection model (Immuncompromized)