Publications

ß-Lactamse inhibitor Program:

  1. Synthesis of Benzhydryl - 2a-(Chloromethyl)-2b-methyl-6,6-dihydropenam-3a-carboxylate 1,1-Dioxide: The 2a-Isomer of the Potent b-Lactamase Inhibitor BL-P2013
    S.N. Maiti, P. Spevak, K. Ogawa, R.G. Micetich
    The Journal of Organic Chemistry, Vol. 53, page 3803, 1988

  2. Synthesis and Beta-Lactamase Inhibitory Activity of 2,2-Bis(Monosubstituted) Methylpenicillin Sulfones
    S.N. Maiti, P. Spevak, R. Wong, A.V.N. Reddy, R.G. Micetich, K. Ogawa
    Heterocycles, Vol. 32, No. 8, 1991

  3. Synthesis and b-Lactamase Inhibitory Activity of 6-[(1-Heteroarylthioethyl-1,2,3-Triazol-4-yl)-Mehtylene]Penam Sulfones
    C. Im, S.N. Maiti, R.G. Micetich, M. Daneshtalab, K. Atchison, O.A. Phillips, C. Kunugita
    The Journal of Antibiotics, Vol. 47, No. 9 pp. 1030 - 1040, Sept., 1994

  4. Synthesis and Biological Evaluation of Sodium 2b-(1,2,3-triazol-1-yl)methyl-6,6-dihydropenam-3 -carboxylate-1,1-dioxide
    S.N. Maiti, P. Spevak, A.V.N. Reddy, R.G. Micetich, N. Ishida, Y. Miyake, K. Ogawa
    Eur. J. Med. Chem, 29. 795-798, June 20, 1994

  5. Chemical Modification of Tazobactam Synthesis of 2b -[(4-Substituted)-1,2,3-triazol-1-yl]methyl Penicillanic Acid Sulfone Derivatives
    E.L. Setti, C. Fiakpui, O.A. Phillips, D.P. Czajkowski, K. Atchison, R.G. Micetich and S.N. Maiti, C. Kunugita, A. Hyodo
    The Journal of Antibiotics, Vol. 48, No. 11, pp. 1320-1329, November, 1995

  6. Synthesis and Biological Evaluation of Sodium 2 b-[(2,5-Dihydro-6-Hydroxy-2-Methyl-5- Oxo-1,2,4-Triazin-3-Yl)Sulfonylmethyl]-2a -Methylpenam-3 -Carboxylate 1,1-Dioxide
    E.L. Setti, O.A. Phillips, A.V.N. Reddy, C. Kunugita, A. Hyodo, R.G. Micetich, S.N. Maiti
    Heterocycles, Vol. 42, No. 2, 645-651,1996

  7. b-Lactamase Inhibitors: Synthesis and In Vitro Evaluation of 6-[(1-Substituted-1,2,3-Triazol-4-Yl)Methylene]-Penicillanic Acid Sulfones
    P. Eby, M.D. Cummings, O.A. Phillips, D.P. Czajkowski, M.P.Singh, P. Spevak, R.G.Micetich, S.N. Maiti
    Heterocycles, Vol. 42, No. 2, 653-668,1996

  8. Studies on Penam Sulfones. I. Synthesis and b -Lactamase Inhibitory Activity of 2 -Alkoxycarbonyl Penicillanic Acid Sulfones
    Eduardo L. Setti, Narender A. Reddy, Oludotun A. Phillips, David P. Czajkowski, Kevin Atchison, Harninder Atwal, Ronald G. Micetich, Samarendra N. Maiti, Chieko Kunugita and Akio Hyodo
    The Journal of Antibiotics, Vol. 49, No. 9 pp.944-946, September 1996

  9. Studies on Penam Sulfones II. Synthesis and b-Lactamase Inhibitory Activity of 2b-Carboxamide Penicillanic Acid Sulfones
    Narender A.V. Reddy, Eduardo L. Setti, Oludotun A. Phillips, David P. Czajkowski, Harninder Atwal, Kevin Atchison, Ronald G. Micetich and Samarendra N. Maiti
    The Journal of Antibiotics, Vol. 50, No. 3, pp. 276-278, March 1997

  10. Studies on Penam Sulfones III. Synthesis and b-Lactamase Inhibitory Activity of Sodium (6R)-6-( a-Hydroxybenzyl)-2 b-Methoxyiminomethyl-2 a-Methylpenam-3a-Carboxylate 1,1-Dioxide and Sodium 2 b-Acyl-2a-Methylpenam-3a-Carboxylate 1,1-Dioxide
    David P. Czajkowski, Andhe V.N. Reddy, Eduardo L. Setti, Oludotun A. Phillips, Ronald G. Micetich, Cheeko Kunugita and Samarendra N. Maiti
    Bioorganic & Medicinal Chemistry Letters, Vol. 7, No. 1, pp. 11-14, 1997

  11. Current Approaches to Overcome Bacterial Resistance
    E.L. Setti, L. Quattrocchio and R. G. Micetich
    Drugs of the Future, 22(3): 271-284,1997

  12. Syn-1012: A New b-Lactamase Inhibitor of Penem Skeleton
    Oludotun A. Phillips, David P. Czajkowski, Paul Spevak, Maya P. Singh, Chieko Hanehara-Kunugita, Akio Hyodo, Ronald G. Micetich and Samarendra N. Maiti
    The Journal of Antibiotics, Vol. 50, No. 4, pp. 350-356, April 1997

  13. Studies on Monobactams I. Synthesis and ß-Lactamase Inhibitory Activity of 4-Substituted 3-[(N- Methyl- 1,2,3-Triazol-4-yl)-Methylene]-2-Azetidinone-1-Sulfonates
    Oludotun A. Phillips, David P. Czajkowski, Kevin Atchison, Ronald G. Micetich, Samarendra N. Maiti, Chieko Kunugita, Akio Hyodo
    Chemistry of Heterocyclic Compounds, No. 11 - C.1536-1547,1998

  14. Studies on Monobactams II. Synthesis and ß-Lactamase Inhibitory Activity of 4a -Methyl-3-[(Thien-2- yl)-Methylene]-2-Azetidinone-1-Sulfonate
    Oludotun A. Phillips, Eduardo L. Setti, Andhe V.N. Reddy, Ronald G. Micetich, Chieko Kunugita, Akio Hyodo, Samarendra N. Maiti
    Chemistry of Heterocyclic Compounds, No. 11 - C.1548-1552,1998

  15. ß-Lactamase Inhibitors: Agents to Overcome Bacterial Resistance
    Samarendra N. Maiti, Oludotun A. Phillips, Ronald G. Micetich, David M. Livermore
    Current Medicinal Chemistry, 5, 441-456,1998 16.

  16. In Vitro and In Vivo Activities of Syn-2190, a Novel ß-Lactamase Inhibitor
    Kouichi Nishida, Chieko Kunugita, Tatsuya Uji, Fusahiro Higashitani, Akio Hyodo, Norio Unemi, Samarendra N. Maiti, Oludotun A. Phillips, Paul Spevak, Kevin P. Atchison, Sameeh M. Salama, Harinder Atwal, Ronald G. Micetich
    Antimicrobial Agents and Chemotherapy, Vol. 43, No. 8, p. 1895 - 1900, Aug. 1999


ß-Lactam Antibiotics/Antibacterial Program:

  1. Oxidation Studies on b-Lactam Antibiotics: 2b-Heteroarylthiomethylpenams
    R. Singh, M.P. Singh, R.G. Micetich
    Heterocycles, Vol. 29, No. 5, 1989

  2. Synthesis and In Vitro Antibacterial Activity of Sodium 6b -[2-(2-Aminothiazol-4-yl)-(Z)-2-Methoxyiminoacetamido]Penicillinate, It's 1b-sulfoxide and 1,1-Dioxide
    R. Singh, M.P. Singh, R.G. Micetich
    The Journal of Antibiotics, Vol. 42, No. 4, pp. 637-639, April 1989

  3. Antibacterial activity and penicillin-binding protein affinity of new cephalosporin derivatives in Staphylococcus aureus and Escherichia coli
    M.P. Singh, Y.I. Lee, R. Singh, R.G. Micetich, B. J. Wilkinson
    Journal of Antimicrobial Chemotherapy, Vol. 27, 459-468, 1991

  4. Synthesis and in vitro antibacterial activity of 2b and 2a -(substituted methyl) phenoxymethylpenicillins and an oxidation product
    M.P. Singh, A.V.N. Reddy, R. Singh, R.G. Micetich
    Eur. J. Med. Chem, Vol. 26, 791-797, 1991

  5. Oxidation Studies on b-Lactam Antibiotics: In-Vitro Antimicrobial Activity of the Oxidized Products of 3-Heteroarylthiomethyl-Ceph-3-Ems
    R. Singh, M.P. Singh, R.G. Micetich
    Collect. Czech. Chem. Commun., Vol. 56, pp. 2362, 1991

  6. Synthesis and in vitro antimicrobial activity of 3-heteroarylsulphonylmethyl cephems: a new class of cephalosporins
    M.P. Singh, R. Singh, S.N. Maiti, P. Spevak, N. Ishida, A. Hyodo, R.G. Micetich
    Eur J. Med. Chem, 30, 157 - 164,1995

  7. In Vitro Antimicrobial Acitivity and Structure-activity Relationship of C-2 Triazolylthio and Pyridinylmethylthio Carbapenems
    C. Fiakpui, G. Thomas, M.P. Singh, R.G. Micetich, R. Singh
    The Journal of antibiotics, Vol. 49, No. 2, pp. 212-215, February 1996

  8. The Effects of Macrolide and Quinolone Antibiotics in Methicillin-Resistant Staphylococcus aureus Biofilm Growth
    Mrinal K. Dasgupta, Harumi Shishido, Sameeh Salama, Rajeshwar Singh, Marlene Larabie, Ronald G. Micetich
    Advances in Peritoneal Dialysis, Vol. 13, 1997

  9. New Trends in Antimicrobial Development
    E.L. Setti and R. G. Micetich
    Current Medicinal Chemistry, 5, 101-113,1998

  10. Synthesis of the novel antibacterial 6,8-dihydroxy-7-propyl-9H-pyrrolo{1,2-b][1,3]-benzoxazin-9-one.
    Liren Hunag, Edmund L. Ellsworth, Sab Randhawa, Michael A. Stier, Yanting Huang, Paul Bird, Mikhail Lebedev, Kun Wu, Ron G. Micetich, John M. Domagala, Rajeshwar Singh and Norm L. Colbry
    Tetrahedron Lett: 41, 4061-4064, 2000


Elastase Inhibitor Program:

  1. Preparation of 7-Spiroepoxy and 7,7-Disubstituted Cephalosporanate 1,1-Dioxide from 7-Diazocephalosporanate 1,1-Dioxide: Reactions of 7-Diazocephalosporanate 1,1-Dioxide with Aldehydes
    D. Czajkowski, O.A. Phillips, A.V.N. Reddy, P. Spevak, B. Lix, R.G. Micetich, S.N. Maiti
    Collect. Czech. Chem. Commun., Vol. 56, pp. 2352, 1991

  2. 2a -Alkoxymethyl Cephalosporins: Reactions of exo-2-methylene Cephalosporin Sulfones with Alcohols
    M.D. Cummings, D.P. Czajkowski, J. Brunstein, N.A.V. Reddy, O.A. Phillips, C.Fiakpui, P.Spevak, R.G. Micetich and S.N. Maiti
    Collect. Czech. Chem. Commun. (Vol. 59) (1994)

  3. Synthesis of 7a -Methoxy-2-(1,3-Dithiolan-2-Ylidene)Cephem Sulphones. A New Series of Human Leukocyte Elastase Inhibitors
    S.N. Maiti, D. Czajkowski, N.A.V. Reddy, P. Spevak, J. Kaleta and R. G. Micetich
    Bio & Med. Chem. Let. Vol 6, No. 7, 823-6, 1996

  4. 7a -Methoxy- 2-[(Substituted)Methylene]Cephem Sulfones as Inhibitors of Human Leukocyte Elastase and Thrombin
    Andhe V. Narender Reddy, Charles Y. Fiakpui, David P. Czajkowski, Jadwiga Kaleta, Ronald G. Micetich, Samarendra N. Maiti
    Chemistry of Heterocyclic Compounds -No. 11 - C.1510-1516,1998

  5. Synthesis and Human Leukocyte Elastase Inhibitory Activity of Novel 2-Spiro(2',2'-Diphenylcyclopropane) Cephalosporin Sulfones
    Andhe V. Narender Reddy, Charles Y. Fiakpui, David P. Czajkowski, Paul Spevak, Jadwiga Kaleta, Ronald G. Micetich, Samarendra N. Maiti
    Chemistry of Heterocyclic Compounds -No. 11 - C.1517-1523,1998

  6. 2-Spirocyclopropyl cephem sulfoens: human neutrophil elastase inhibitors Syn-1390 and Syn-1396
    Samarendra N. Maiti, Donald E. Woods and Andre M. Cantin
    Drugs of the Future, 23(6); 635-641,1998

  7. A rapid and reliable solid-phase extraction - LC/MS/MS assay for the determinationof two novel human Leucocyte elasate inhibitor SYN-1390 and SYN 1396 in rat plasma
    Jehangir K. Khan, Hai-Zhi Bu, Zhong Zuo, Samarendra N. Maiti, Ronald G. Mcietich
    Journal of Pharmaceutical And Biomedical Analysis, 20, 697 - 703,1999


Antifungal Program:

  1. Preparations of liposomal fluconazole and their in vitro antifungal activity
    M. Singh, M.P. Singh, S.N. Maiti, A. Gandhi, R.G. Micetich, H. Atwal
    J. Microencapsulation, Vol. 19, No. 2, 229-236, 1993

  2. The Synthesis of Aminimide-Containing Azole Antifungals
    Mark D. Abel, Randy T. Hewgill, Katherine J. Malczyk, Ronald G. Micetich and Mohsen Deaneshtalab
    J. Heterocyclic Chem., 35, 193, Jan-Feb. 1998

  3. Structure Elucidation of Three Isomeric Metabolites of Syn-2836, a Novel Antifungal Agent, in Dogs via Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Tandem Mass Spectrometry Methodologies
    Hai-Zhi Bu, Marzena Poglod, Ronald G. Micetich, Jehangir K. Khan
    Journal of Mass Spectrometry, 34, 2286 - 1194, 1999

  4. High-performance liquid chromatographic analysis of new triazole antifungal agent Syn-2869 and its derivatives in plasma
    Jehangir K. Khan, Hashem Montaseri, Marzena Poglod, Hai-Zhi Bu, Mohsen Daneshtalab, Ronald G. Micetich
    Journal of Pharmaceutical and Biomedical Analysis, 20, 791-797,1999

  5. Novel sample preparation method facilitating identification of urinary drug metabolites by liquid chromatography - tandem mass spectrometry
    Hai-Zhi Bu, Marzena Poglod, Ronald G. Micetich, Jehangir K. Khan
    Journal of Chromatography B, 738, 259-265,2000

  6. Interspecies Comparison of Pharmacokinetics of the Novel Triazole Antifungal Agent SYN-2869 and Its Derivatives
    Jehangir K. Khan, Hashem Montaseri, Marzena Poglod, Hai-Zhi Bu, Zhong Zuo, Sameeh M. Salama, Mohsen Daneshtalab, Ronald G. Micetich
    Antimicrobial Agents and Chemotherapy, 44(4, p. 910 -915,2000

  7. Liquid chromatographic-electrospray tandem mass spectrometric determination of novel antifungal agents, SYN-2869 and its derivatives, in plasma.
    Hai-Zhi Bu, Jehangir K. Khan, Marzena Poglod and Ronald G. Micetich
    Journal of Chromatography B, Biomedical Sciences and application, 724, 311-317,1999

  8. High-performance liquid chromatographic assay for the determination of novel triazole antifungal agents in tissue. Application to tissue distribution studies
    Jehangir K. Khan, Hashem Montaseri, Marzena Poglod, Hai-Zhi Bu, Mohsen Daneshtalab and Ronald G, Micetich
    Biomedical chromatography 14:321-326,2000

  9. In vitro and in vivo activity of SYN 2836, SYN 2869, SYN 2903 and SYN 2921: a new class of triazole antifungal agents.
    Salama, S.M., H. Atwal, A. Gandhi, J. Simon, M. Poglod, H. Montaseri, J. Khan, T. Furukawa, H. Saito, K. Nishida, F. Higashitani, T. Uji, N. Unemi, M. Daneshtalab and R.G. Micetich
    (2001) Antimicrobial agents and chemotherapy (in press)

  10. Practical aspects of liquid chromatography-electrospray tandem mass spectrometry for rapid identification Of metabolite of a new antifungal agent SYN-2836 in dog urine
    Hai-Zhi Bu, Marzena Poglod, Ronald G. Micetich and Jehangir K. Khan
    Rapid Communication in Mass Spectrometry, 2001 (in press)


Anti Cancer Program:

  1. Synthesis of Manwuweizic Acid, An Anticancer Triterpenoid
    J.S. Liu, Y. Tao
    Tetrahedron, Vol. 48, No. 33, pp. 6793-6798, 1992

  2. Synthetic Studies Towards Taxol Analogs: Chemoselective Cleavage of C-5 Cinnamoyl Group in Taxane Group of Diterpenoids with Hydroxylamine
    Y. Bathini, R.G.Micetich, M. Daneshtalab
    Synthetic Communications, 24(22), 1513-1517, 1994

  3. Synthesis of Ring-A-Opened Isopicropodophyllins As Potential DNA Topoisomerase II Inhibitors
    A. Kamal, M. Daneshtalab, K. Atchison, R.G. Micetich
    Bioorganic & Medicinal Chemistry Letters, Vol. 4, No. 12, pp. 1513-1518, 1994

  4. A Rapid Entry Into Podophyllotoxin Congeners: Synthesis of Justicidin B
    A. Kamal, M. Daneshtalab, R. G. Micetich
    Tetrahedron Letters, Vol. 35, No. 23, pp. 3879-3882, 1994

  5. Synthesis of podophyllotoxin congeners as potential DNA topoisomerase II inhibitors
    A. Kamal, K. Atchison, M. Daneshtalab and R. Micetich
    Anti-Cancer Drug Design, 10, 545-554,1995

  6. Synthesis of Azolylalkylquinolines with Cytotoxic Activity
    Mark D. Abel, Hiep T. Luu, Ronald G. Micetich, Dai Q. Nguyen, A. Bernadette Oreski, Mark L. Tempest and Mohsen Daneshtalab
    J. Heterocyclic Chem., 33, 415, Mar-Apr 1996

  7. Cytotoxic Quinolines (Part 1). Azolylalkyloxy Quinolines and 1-Azolylalkyl-4(1H)-Quinolones
    M.D. Abel, C.M. Ha, H.T. Luu, R.G. Micetich, D.Q. Nguyen, M. Nukatsuka, A.B. Oreski, M.L. Tempest, M. Daneshtalab
    Drug Design and Discovery, Vol. 14, pp. 15 - 30,1996

  8. Cytotoxic Quinolines (Part 2). Azolylalkylamino and -Thio Quinolines
    M.D. Abel, C.M. Ha, H.T. Luu, R.G. Micetich, D.Q. Nguyen, M. Nukatsuka, A.B. Oreski, M.L. Tempest, M. Daneshtalab
    Drug Design and Discovery, Vol. 14, pp. 31 - 42,1996

  9. Cytotoxic Quinolines (Part 3)1. Synthesis of 1-Azolylalkyl-4(1H)-Quinolones as Cytotoxic Agents
    Mark Abel, Ronald G. Micetich, Mamoru Nukatsuka, A. Bernadette Oreski, Mark L. Tempest and Mohsen Daneshtalab
    Drug Design and Discovery, Vol. 14, pp. 115-127, 1996


Chemistry:

  1. 1H and 13C NMR Studies of Third-Generation Cephalosporin Esters Sulphoxides and Sulphones
    M. Lee, R.G. Micetich, R. Singh, P. Spevak, M. P. Singh, S.N. Maiti
    Magnetic Resonance in Chemistry, Vol. 26, 719-721 (1988) (Reference Data)

  2. A Mild and Efficient Cleavage of Symmetrical Disulphides using Semicarbazide and Thiosemicarbazide
    S.N. Maiti, M.P. Singh, P. Spevak, R.G. Micetich, A.V.N. Reddy
    J. Chem. Research (S), 256-257, 1988

  3. Studies on Reactive Intermediates. Part VI. 1) Synthesis of Benzo(a)Quinolizines via Methylketene Dimer
    M. Daneshtalab, R.G. Micetich, S. Forghanifar
    Heterocycles, Vol. 27, No. 3, 1988

  4. The Chemistry of the 6b-Diacylaminopenicillins
    R.G. Micetich, R. Singh, C.C. Shaw, S.N. Maiti, M.P. Singh, P. Spevak
    Heterocycles, Vol. 29, No. 1, 1989

  5. A One Pot Synthesis of 1-substituted-1,2,3,7-Tetrahyodro-8-Nitroimidazo[1,2-a][1,2,6] Thiadiazine-7 (1H)One-5,5-Dioxides
    A.V.N. Reddy, S.N. Maiti, I.P. Singh, R.G. Micetich
    Synthetic Communications, 19(17), 3021-3025 (1989)

  6. The Chemistry of the 6b-Thioamidopenam 1 b-Sulfoxides. The 1,2,4-Dithiazineazetidinones and Thiazolineazetidinones
    R.G. Micetich, R. Singh, D.M. Tetteh, R.B. Morin
    Heterocycles, Vol. 31, No. 9, 1990

  7. Reactions of Diketene: A One Pot Synthesis of 1,5-Disubstituted 1,2,3,7-Tetrahydro-8-nitroimidazol[1,2-a]-pyridin-7(1H)-ones and 1-Methyl-4-nitropyrido[1,2-a]-benzimidazol-3(5H)-one
    A.V.N. Reddy, S.N. Maiti, R.G. Micetich
    J. Chem. Research (S), 32-33, 1990

  8. Oxidation studies on b-lactam antibiotics: Determination of structures of oxidation products of 3-heteroarylthiomethylcephalosporin using NMR spectroscopy
    R. Singh, M.P. Singh, R.G. Micetich
    Indian Journal of Chemistry, Vol. 30B, pp.176-181, Feb. 1991

  9. Conversion of Cis-Aldehydes to Trans-Aldehydes Using Thioacetamide or Thiourea
    O.A. Phillips, P. Eby and S.N. Maiti
    Synthetic Communications, 25(1), 87-93 (1995)

  10. 1H NMR and NOE Studies of 6a-Bromopenicillanates
    C. Im, C.B. Yim, B. Lix, R.G. Micetich and M. Daneshtalab
    Arch. Pharm. Res. Vol. 18, No. 1, pp. 48-50, 1995

  11. Murrayanolide, An Unusual C21 Tetracyclic Terpenoid Lactone From The Marine Bryozoan Dendrobeania Murrayana
    Chao-Mei Yu and Jeffrey L.C. Wright
    Journal of Natural Products, Vol. 58, No. 12, pp 1978-1982, December 1995

  12. Modern Drug Design and Lead Discovery: An Overview
    E.L. Setti and R. Micetich
    Current Medicinal Chemistry, 3, 317-324,1996

  13. Monobactams as enzyme inhibitors
    Rajeshwar Singh and Ronald Micetich
    Idrugs 3(5); 512-517, 2000


Anti-Viral Program:

  1. Novel azolylalkyloxy compounds with antipicornaviral activity
    M.D. Abel, A.D. Cameron, C.M. Ha, C.A. Koski, H.T. Luu, R.G. Micetich, D.Q. Nguyen, M.L. Tempest, M. Daneshtalab
    Antiviral Chemistry & Chemotherapy, 6(4), 245-254,1995

  2. Novel Azolylalkylthio, -Sulfoxxy, and -Sulfonyl Compounds with Antipicornaviral Activity
    M. Daneshtalab, M.D. Abel, A.D. Cameron, H.T. Luu, R. G. Micetich, D.Q. Nguyen and M.L. Tempest
    J. Sci. I.R. Iran, Vol. 8 No. 1, Winter 1997


Cysteine Protease Program:

  1. Potent Inhibitors of Cysteine Proteases from the Marine Fungus Microascus longirostris
    Chao-Mei Yu, Jonathan M. Curtis, John A. Walter, Jeffrey L.C. Wright, Stephen W. Ayer, Jadwiga Kaleta, Lori Querengesser and Ziba R. Fathi-Afshar
    The Journal of Antibiotics, Vol. 49, No. 4 pp. 395-397, April 1996


General Pharmaceutical Sciences:

  1. Sensitive High-Performance Liquid Chromatographic Assay for Norfloxacin Utilizing Fluorescence Detection
    M.S. Hussain, V.C. Obiajunwa and R.G. Micetich
    Journal of Chromatography B, 663, 379-384, (1995)

  2. High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry
    Hai-Zhi Bu, Marzena Poglod, Ronald G. Micetich and Jehangir K. Khan
    Rapid Communications in Mass Spectrometry, 14, 523-528 (2000) Content coming soon