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Publications
ß-Lactamse inhibitor Program:
- Synthesis of Benzhydryl - 2a-(Chloromethyl)-2b-methyl-6,6-dihydropenam-3a-carboxylate 1,1-Dioxide: The 2a-Isomer of the Potent b-Lactamase Inhibitor BL-P2013
S.N. Maiti, P. Spevak, K. Ogawa, R.G. Micetich
The Journal of Organic Chemistry, Vol. 53, page 3803, 1988
- Synthesis and Beta-Lactamase Inhibitory Activity of 2,2-Bis(Monosubstituted) Methylpenicillin Sulfones
S.N. Maiti, P. Spevak, R. Wong, A.V.N. Reddy, R.G. Micetich, K. Ogawa
Heterocycles, Vol. 32, No. 8, 1991
- Synthesis and b-Lactamase Inhibitory Activity of 6-[(1-Heteroarylthioethyl-1,2,3-Triazol-4-yl)-Mehtylene]Penam Sulfones
C. Im, S.N. Maiti, R.G. Micetich, M. Daneshtalab, K. Atchison, O.A.
Phillips, C. Kunugita
The Journal of Antibiotics, Vol. 47, No. 9 pp.
1030 - 1040, Sept., 1994
- Synthesis and Biological Evaluation of
Sodium 2b-(1,2,3-triazol-1-yl)methyl-6,6-dihydropenam-3
-carboxylate-1,1-dioxide
S.N. Maiti, P. Spevak, A.V.N. Reddy, R.G.
Micetich, N. Ishida, Y. Miyake, K. Ogawa
Eur. J. Med. Chem, 29. 795-798,
June 20, 1994
- Chemical Modification of Tazobactam Synthesis of 2b
-[(4-Substituted)-1,2,3-triazol-1-yl]methyl Penicillanic Acid Sulfone
Derivatives
E.L. Setti, C. Fiakpui, O.A. Phillips, D.P. Czajkowski, K.
Atchison, R.G. Micetich and S.N. Maiti, C. Kunugita, A. Hyodo
The Journal of Antibiotics, Vol. 48, No. 11, pp. 1320-1329, November, 1995
- Synthesis and Biological Evaluation of Sodium 2
b-[(2,5-Dihydro-6-Hydroxy-2-Methyl-5-
Oxo-1,2,4-Triazin-3-Yl)Sulfonylmethyl]-2a
-Methylpenam-3 -Carboxylate 1,1-Dioxide
E.L. Setti, O.A. Phillips, A.V.N. Reddy, C. Kunugita, A.
Hyodo, R.G. Micetich, S.N. Maiti
Heterocycles, Vol. 42, No. 2, 645-651,1996
- b-Lactamase Inhibitors: Synthesis and In Vitro Evaluation
of 6-[(1-Substituted-1,2,3-Triazol-4-Yl)Methylene]-Penicillanic Acid
Sulfones
P. Eby, M.D. Cummings, O.A. Phillips, D.P. Czajkowski,
M.P.Singh, P. Spevak, R.G.Micetich, S.N. Maiti
Heterocycles, Vol. 42, No. 2, 653-668,1996
- Studies on Penam Sulfones. I. Synthesis and b
-Lactamase Inhibitory Activity of 2 -Alkoxycarbonyl Penicillanic Acid
Sulfones
Eduardo L. Setti, Narender A. Reddy, Oludotun A. Phillips,
David P. Czajkowski, Kevin Atchison, Harninder Atwal, Ronald G.
Micetich, Samarendra N. Maiti, Chieko Kunugita and Akio Hyodo
The Journal of Antibiotics, Vol. 49, No. 9 pp.944-946, September 1996
- Studies on Penam Sulfones II. Synthesis and b-Lactamase Inhibitory
Activity of 2b-Carboxamide Penicillanic Acid Sulfones
Narender A.V. Reddy, Eduardo L. Setti, Oludotun A. Phillips, David P. Czajkowski,
Harninder Atwal, Kevin Atchison, Ronald G. Micetich and Samarendra N.
Maiti
The Journal of Antibiotics, Vol. 50, No. 3, pp. 276-278, March
1997
- Studies on Penam Sulfones III. Synthesis and b-Lactamase
Inhibitory Activity of Sodium (6R)-6-( a-Hydroxybenzyl)-2
b-Methoxyiminomethyl-2 a-Methylpenam-3a-Carboxylate 1,1-Dioxide and Sodium 2 b-Acyl-2a-Methylpenam-3a-Carboxylate 1,1-Dioxide
David P. Czajkowski,
Andhe V.N. Reddy, Eduardo L. Setti, Oludotun A. Phillips, Ronald G.
Micetich, Cheeko Kunugita and Samarendra N. Maiti
Bioorganic & Medicinal Chemistry Letters, Vol. 7, No. 1, pp. 11-14, 1997
- Current Approaches to Overcome Bacterial Resistance
E.L. Setti, L. Quattrocchio and R. G. Micetich
Drugs of the Future, 22(3): 271-284,1997
- Syn-1012: A New b-Lactamase Inhibitor of Penem Skeleton
Oludotun A. Phillips, David P. Czajkowski, Paul Spevak, Maya P. Singh, Chieko
Hanehara-Kunugita, Akio Hyodo, Ronald G. Micetich and Samarendra N.
Maiti
The Journal of Antibiotics, Vol. 50, No. 4, pp. 350-356, April
1997
- Studies on Monobactams I. Synthesis and ß-Lactamase Inhibitory
Activity of 4-Substituted 3-[(N- Methyl-
1,2,3-Triazol-4-yl)-Methylene]-2-Azetidinone-1-Sulfonates
Oludotun A. Phillips, David P. Czajkowski, Kevin Atchison, Ronald G. Micetich,
Samarendra N. Maiti, Chieko Kunugita, Akio Hyodo
Chemistry of Heterocyclic Compounds, No. 11 - C.1536-1547,1998
- Studies on Monobactams II. Synthesis and ß-Lactamase Inhibitory Activity of 4a
-Methyl-3-[(Thien-2- yl)-Methylene]-2-Azetidinone-1-Sulfonate
Oludotun A. Phillips, Eduardo L. Setti, Andhe V.N. Reddy, Ronald G. Micetich,
Chieko Kunugita, Akio Hyodo, Samarendra N. Maiti
Chemistry of Heterocyclic Compounds, No. 11 - C.1548-1552,1998
- ß-Lactamase Inhibitors: Agents to Overcome Bacterial Resistance
Samarendra N. Maiti,
Oludotun A. Phillips, Ronald G. Micetich, David M. Livermore
Current Medicinal Chemistry, 5, 441-456,1998 16.
- In Vitro and In Vivo Activities
of Syn-2190, a Novel ß-Lactamase Inhibitor
Kouichi Nishida, Chieko
Kunugita, Tatsuya Uji, Fusahiro Higashitani, Akio Hyodo, Norio Unemi,
Samarendra N. Maiti, Oludotun A. Phillips, Paul Spevak, Kevin P.
Atchison, Sameeh M. Salama, Harinder Atwal, Ronald G. Micetich
Antimicrobial Agents and Chemotherapy, Vol. 43, No. 8, p. 1895 - 1900, Aug. 1999
ß-Lactam Antibiotics/Antibacterial Program:
- Oxidation
Studies on b-Lactam Antibiotics: 2b-Heteroarylthiomethylpenams
R. Singh,
M.P. Singh, R.G. Micetich
Heterocycles, Vol. 29, No. 5, 1989
-
Synthesis and In Vitro Antibacterial Activity of Sodium 6b
-[2-(2-Aminothiazol-4-yl)-(Z)-2-Methoxyiminoacetamido]Penicillinate,
It's 1b-sulfoxide and 1,1-Dioxide
R. Singh, M.P. Singh, R.G. Micetich
The Journal of Antibiotics, Vol. 42, No. 4, pp. 637-639, April 1989
- Antibacterial activity and penicillin-binding protein affinity of new
cephalosporin derivatives in Staphylococcus aureus and Escherichia coli
M.P. Singh, Y.I. Lee, R. Singh, R.G. Micetich, B. J. Wilkinson
Journal of Antimicrobial Chemotherapy, Vol. 27, 459-468, 1991
- Synthesis and
in vitro antibacterial activity of 2b and 2a -(substituted methyl)
phenoxymethylpenicillins and an oxidation product
M.P. Singh, A.V.N.
Reddy, R. Singh, R.G. Micetich
Eur. J. Med. Chem, Vol. 26, 791-797, 1991
- Oxidation Studies on b-Lactam Antibiotics: In-Vitro Antimicrobial
Activity of the Oxidized Products of 3-Heteroarylthiomethyl-Ceph-3-Ems
R. Singh, M.P. Singh, R.G. Micetich
Collect. Czech. Chem. Commun., Vol. 56, pp. 2362, 1991
- Synthesis and in vitro antimicrobial activity of
3-heteroarylsulphonylmethyl cephems: a new class of cephalosporins
M.P. Singh, R. Singh, S.N. Maiti, P. Spevak, N. Ishida, A. Hyodo, R.G.
Micetich
Eur J. Med. Chem, 30, 157 - 164,1995
- In Vitro Antimicrobial
Acitivity and Structure-activity Relationship of C-2 Triazolylthio and
Pyridinylmethylthio Carbapenems
C. Fiakpui, G. Thomas, M.P. Singh, R.G.
Micetich, R. Singh
The Journal of antibiotics, Vol. 49, No. 2, pp.
212-215, February 1996
- The Effects of Macrolide and Quinolone
Antibiotics in Methicillin-Resistant Staphylococcus aureus Biofilm
Growth
Mrinal K. Dasgupta, Harumi Shishido, Sameeh Salama, Rajeshwar
Singh, Marlene Larabie, Ronald G. Micetich
Advances in Peritoneal
Dialysis, Vol. 13, 1997
- New Trends in Antimicrobial Development
E.L. Setti and R. G. Micetich
Current Medicinal Chemistry, 5, 101-113,1998
- Synthesis of the novel antibacterial
6,8-dihydroxy-7-propyl-9H-pyrrolo{1,2-b][1,3]-benzoxazin-9-one.
Liren Hunag, Edmund L. Ellsworth, Sab Randhawa, Michael A. Stier, Yanting
Huang, Paul Bird, Mikhail Lebedev, Kun Wu, Ron G. Micetich, John M.
Domagala, Rajeshwar Singh and Norm L. Colbry
Tetrahedron Lett: 41, 4061-4064, 2000
Elastase Inhibitor Program:
- Preparation of
7-Spiroepoxy and 7,7-Disubstituted Cephalosporanate 1,1-Dioxide from
7-Diazocephalosporanate 1,1-Dioxide: Reactions of
7-Diazocephalosporanate 1,1-Dioxide with Aldehydes
D. Czajkowski, O.A.
Phillips, A.V.N. Reddy, P. Spevak, B. Lix, R.G. Micetich, S.N. Maiti
Collect. Czech. Chem. Commun., Vol. 56, pp. 2352, 1991
- 2a
-Alkoxymethyl Cephalosporins: Reactions of exo-2-methylene Cephalosporin
Sulfones with Alcohols
M.D. Cummings, D.P. Czajkowski, J. Brunstein,
N.A.V. Reddy, O.A. Phillips, C.Fiakpui, P.Spevak, R.G. Micetich and S.N.
Maiti
Collect. Czech. Chem. Commun. (Vol. 59) (1994)
- Synthesis of 7a
-Methoxy-2-(1,3-Dithiolan-2-Ylidene)Cephem Sulphones. A New Series of
Human Leukocyte Elastase Inhibitors
S.N. Maiti, D. Czajkowski, N.A.V.
Reddy, P. Spevak, J. Kaleta and R. G. Micetich
Bio & Med. Chem. Let. Vol 6, No. 7, 823-6, 1996
- 7a -Methoxy-
2-[(Substituted)Methylene]Cephem Sulfones as Inhibitors of Human
Leukocyte Elastase and Thrombin
Andhe V. Narender Reddy, Charles Y.
Fiakpui, David P. Czajkowski, Jadwiga Kaleta, Ronald G. Micetich,
Samarendra N. Maiti
Chemistry of Heterocyclic Compounds -No. 11 - C.1510-1516,1998
- Synthesis and Human Leukocyte Elastase Inhibitory
Activity of Novel 2-Spiro(2',2'-Diphenylcyclopropane) Cephalosporin
Sulfones
Andhe V. Narender Reddy, Charles Y. Fiakpui, David P.
Czajkowski, Paul Spevak, Jadwiga Kaleta, Ronald G. Micetich, Samarendra
N. Maiti
Chemistry of Heterocyclic Compounds -No. 11 - C.1517-1523,1998
- 2-Spirocyclopropyl cephem sulfoens: human neutrophil elastase
inhibitors Syn-1390 and Syn-1396
Samarendra N. Maiti, Donald E. Woods
and Andre M. Cantin
Drugs of the Future, 23(6); 635-641,1998
- A rapid
and reliable solid-phase extraction - LC/MS/MS assay for the
determinationof two novel human Leucocyte elasate inhibitor SYN-1390 and
SYN 1396 in rat plasma
Jehangir K. Khan, Hai-Zhi Bu, Zhong Zuo,
Samarendra N. Maiti, Ronald G. Mcietich
Journal of Pharmaceutical And
Biomedical Analysis, 20, 697 - 703,1999
Antifungal Program:
-
Preparations of liposomal fluconazole and their in vitro antifungal
activity
M. Singh, M.P. Singh, S.N. Maiti, A. Gandhi, R.G. Micetich, H.
Atwal
J. Microencapsulation, Vol. 19, No. 2, 229-236, 1993
- The Synthesis of Aminimide-Containing Azole Antifungals
Mark D. Abel, Randy
T. Hewgill, Katherine J. Malczyk, Ronald G. Micetich and Mohsen
Deaneshtalab
J. Heterocyclic Chem., 35, 193, Jan-Feb. 1998
- Structure
Elucidation of Three Isomeric Metabolites of Syn-2836, a Novel
Antifungal Agent, in Dogs via Liquid Chromatography/Mass Spectrometry
and Liquid Chromatography/Tandem Mass Spectrometry Methodologies
Hai-Zhi
Bu, Marzena Poglod, Ronald G. Micetich, Jehangir K. Khan
Journal of Mass
Spectrometry, 34, 2286 - 1194, 1999
- High-performance liquid
chromatographic analysis of new triazole antifungal agent Syn-2869 and
its derivatives in plasma
Jehangir K. Khan, Hashem Montaseri, Marzena
Poglod, Hai-Zhi Bu, Mohsen Daneshtalab, Ronald G. Micetich
Journal of Pharmaceutical and Biomedical Analysis, 20, 791-797,1999
- Novel sample
preparation method facilitating identification of urinary drug
metabolites by liquid chromatography - tandem mass spectrometry
Hai-Zhi
Bu, Marzena Poglod, Ronald G. Micetich, Jehangir K. Khan
Journal of Chromatography B, 738, 259-265,2000
- Interspecies Comparison of
Pharmacokinetics of the Novel Triazole Antifungal Agent SYN-2869 and Its
Derivatives
Jehangir K. Khan, Hashem Montaseri, Marzena Poglod, Hai-Zhi
Bu, Zhong Zuo, Sameeh M. Salama, Mohsen Daneshtalab, Ronald G. Micetich
Antimicrobial Agents and Chemotherapy, 44(4, p. 910 -915,2000
- Liquid
chromatographic-electrospray tandem mass spectrometric determination of
novel antifungal agents, SYN-2869 and its derivatives, in plasma.
Hai-Zhi Bu, Jehangir K. Khan, Marzena Poglod and Ronald G. Micetich
Journal of Chromatography B, Biomedical Sciences and application, 724,
311-317,1999
- High-performance liquid chromatographic assay for the
determination of novel triazole antifungal agents in tissue. Application
to tissue distribution studies
Jehangir K. Khan, Hashem Montaseri,
Marzena Poglod, Hai-Zhi Bu, Mohsen Daneshtalab and Ronald G, Micetich
Biomedical chromatography 14:321-326,2000
- In vitro and in vivo
activity of SYN 2836, SYN 2869, SYN 2903 and SYN 2921: a new class of
triazole antifungal agents.
Salama, S.M., H. Atwal, A. Gandhi, J. Simon,
M. Poglod, H. Montaseri, J. Khan, T. Furukawa, H. Saito, K. Nishida, F.
Higashitani, T. Uji, N. Unemi, M. Daneshtalab and R.G. Micetich
(2001) Antimicrobial agents and chemotherapy (in press)
- Practical aspects of
liquid chromatography-electrospray tandem mass spectrometry for rapid
identification Of metabolite of a new antifungal agent SYN-2836 in dog
urine
Hai-Zhi Bu, Marzena Poglod, Ronald G. Micetich and Jehangir K.
Khan
Rapid Communication in Mass Spectrometry, 2001 (in press)
Anti Cancer Program:
- Synthesis of Manwuweizic Acid, An Anticancer
Triterpenoid
J.S. Liu, Y. Tao
Tetrahedron, Vol. 48, No. 33, pp.
6793-6798, 1992
- Synthetic Studies Towards Taxol Analogs:
Chemoselective Cleavage of C-5 Cinnamoyl Group in Taxane Group of
Diterpenoids with Hydroxylamine
Y. Bathini, R.G.Micetich, M. Daneshtalab
Synthetic Communications, 24(22), 1513-1517, 1994
- Synthesis of
Ring-A-Opened Isopicropodophyllins As Potential DNA Topoisomerase II
Inhibitors
A. Kamal, M. Daneshtalab, K. Atchison, R.G. Micetich
Bioorganic & Medicinal Chemistry Letters, Vol. 4, No. 12, pp.
1513-1518, 1994
- A Rapid Entry Into Podophyllotoxin Congeners:
Synthesis of Justicidin B
A. Kamal, M. Daneshtalab, R. G. Micetich
Tetrahedron Letters, Vol. 35, No. 23, pp. 3879-3882, 1994
- Synthesis
of podophyllotoxin congeners as potential DNA topoisomerase II
inhibitors
A. Kamal, K. Atchison, M. Daneshtalab and R. Micetich
Anti-Cancer Drug Design, 10, 545-554,1995
- Synthesis of
Azolylalkylquinolines with Cytotoxic Activity
Mark D. Abel, Hiep T. Luu,
Ronald G. Micetich, Dai Q. Nguyen, A. Bernadette Oreski, Mark L. Tempest
and Mohsen Daneshtalab
J. Heterocyclic Chem., 33, 415, Mar-Apr 1996
- Cytotoxic Quinolines (Part 1). Azolylalkyloxy Quinolines and
1-Azolylalkyl-4(1H)-Quinolones
M.D. Abel, C.M. Ha, H.T. Luu, R.G.
Micetich, D.Q. Nguyen, M. Nukatsuka, A.B. Oreski, M.L. Tempest, M.
Daneshtalab
Drug Design and Discovery, Vol. 14, pp. 15 - 30,1996
- Cytotoxic Quinolines (Part 2). Azolylalkylamino and -Thio Quinolines
M.D. Abel, C.M. Ha, H.T. Luu, R.G. Micetich, D.Q. Nguyen, M. Nukatsuka,
A.B. Oreski, M.L. Tempest, M. Daneshtalab
Drug Design and Discovery, Vol. 14, pp. 31 - 42,1996
- Cytotoxic Quinolines (Part 3)1. Synthesis
of 1-Azolylalkyl-4(1H)-Quinolones as Cytotoxic Agents
Mark Abel, Ronald
G. Micetich, Mamoru Nukatsuka, A. Bernadette Oreski, Mark L. Tempest and
Mohsen Daneshtalab
Drug Design and Discovery, Vol. 14, pp. 115-127, 1996
Chemistry:
- 1H and 13C NMR Studies of Third-Generation Cephalosporin
Esters Sulphoxides and Sulphones
M. Lee, R.G. Micetich, R. Singh, P.
Spevak, M. P. Singh, S.N. Maiti
Magnetic Resonance in Chemistry, Vol. 26, 719-721 (1988) (Reference Data)
- A Mild and Efficient Cleavage of
Symmetrical Disulphides using Semicarbazide and Thiosemicarbazide
S.N. Maiti, M.P. Singh, P. Spevak, R.G. Micetich, A.V.N. Reddy
J. Chem. Research (S), 256-257, 1988
- Studies on Reactive Intermediates. Part
VI. 1) Synthesis of Benzo(a)Quinolizines via Methylketene Dimer
M. Daneshtalab, R.G. Micetich, S. Forghanifar
Heterocycles, Vol. 27, No. 3, 1988
- The Chemistry of the 6b-Diacylaminopenicillins
R.G. Micetich, R.
Singh, C.C. Shaw, S.N. Maiti, M.P. Singh, P. Spevak
Heterocycles, Vol. 29, No. 1, 1989
- A One Pot Synthesis of
1-substituted-1,2,3,7-Tetrahyodro-8-Nitroimidazo[1,2-a][1,2,6]
Thiadiazine-7 (1H)One-5,5-Dioxides
A.V.N. Reddy, S.N. Maiti, I.P. Singh,
R.G. Micetich
Synthetic Communications, 19(17), 3021-3025 (1989)
- The Chemistry of the 6b-Thioamidopenam 1 b-Sulfoxides. The
1,2,4-Dithiazineazetidinones and Thiazolineazetidinones
R.G. Micetich,
R. Singh, D.M. Tetteh, R.B. Morin
Heterocycles, Vol. 31, No. 9, 1990
- Reactions of Diketene: A One Pot Synthesis of 1,5-Disubstituted
1,2,3,7-Tetrahydro-8-nitroimidazol[1,2-a]-pyridin-7(1H)-ones and
1-Methyl-4-nitropyrido[1,2-a]-benzimidazol-3(5H)-one
A.V.N. Reddy, S.N.
Maiti, R.G. Micetich
J. Chem. Research (S), 32-33, 1990
- Oxidation studies on b-lactam antibiotics: Determination of structures of oxidation
products of 3-heteroarylthiomethylcephalosporin using NMR spectroscopy
R. Singh, M.P. Singh, R.G. Micetich
Indian Journal of Chemistry, Vol. 30B, pp.176-181, Feb. 1991
- Conversion of Cis-Aldehydes to
Trans-Aldehydes Using Thioacetamide or Thiourea
O.A. Phillips, P. Eby
and S.N. Maiti
Synthetic Communications, 25(1), 87-93 (1995)
- 1H NMR and NOE Studies of 6a-Bromopenicillanates
C. Im, C.B. Yim, B. Lix, R.G.
Micetich and M. Daneshtalab
Arch. Pharm. Res. Vol. 18, No. 1, pp. 48-50, 1995
- Murrayanolide, An Unusual C21 Tetracyclic Terpenoid Lactone
From The Marine Bryozoan Dendrobeania Murrayana
Chao-Mei Yu and Jeffrey L.C. Wright
Journal of Natural Products, Vol. 58, No. 12, pp 1978-1982,
December 1995
- Modern Drug Design and Lead Discovery: An Overview
E.L. Setti and R. Micetich
Current Medicinal Chemistry, 3, 317-324,1996
- Monobactams as enzyme inhibitors
Rajeshwar Singh and Ronald Micetich
Idrugs 3(5); 512-517, 2000
Anti-Viral Program:
- Novel azolylalkyloxy compounds with antipicornaviral activity
M.D. Abel, A.D. Cameron, C.M.
Ha, C.A. Koski, H.T. Luu, R.G. Micetich, D.Q. Nguyen, M.L. Tempest, M.
Daneshtalab
Antiviral Chemistry & Chemotherapy, 6(4), 245-254,1995
- Novel Azolylalkylthio, -Sulfoxxy, and -Sulfonyl Compounds with
Antipicornaviral Activity
M. Daneshtalab, M.D. Abel, A.D. Cameron, H.T.
Luu, R. G. Micetich, D.Q. Nguyen and M.L. Tempest
J. Sci. I.R. Iran, Vol. 8 No. 1, Winter 1997
Cysteine Protease Program:
- Potent Inhibitors of Cysteine Proteases from the Marine Fungus Microascus
longirostris
Chao-Mei Yu, Jonathan M. Curtis, John A. Walter, Jeffrey
L.C. Wright, Stephen W. Ayer, Jadwiga Kaleta, Lori Querengesser and Ziba
R. Fathi-Afshar
The Journal of Antibiotics, Vol. 49, No. 4 pp. 395-397,
April 1996
General Pharmaceutical Sciences:
- Sensitive High-Performance Liquid Chromatographic Assay for Norfloxacin Utilizing
Fluorescence Detection
M.S. Hussain, V.C. Obiajunwa and R.G. Micetich
Journal of Chromatography B, 663, 379-384, (1995)
- High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge
extraction/tandem mass spectrometry
Hai-Zhi Bu, Marzena Poglod, Ronald
G. Micetich and Jehangir K. Khan
Rapid Communications in Mass
Spectrometry, 14, 523-528 (2000) Content coming soon
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